Secrecy Enhancement in Cooperative Relaying Systems

Cooperative communications is obviously an evolution in wireless networks due to its noticeable advantages such as increasing the coverage as well as combating fading and shadowing effects. However, the broadcast characteristic of a wireless medium which is exploited in cooperative communications leads to a variety of security vulnerabilities. As cooperative communication networks are globally expanded, they expose to security attacks and threats more than ever. Primarily, researchers have focused on upper layers of network architectures to meet the requirements for secure cooperative transmission while the upper-layer security solutions are incapable of combating a number of security threats, e.g., jamming attacks. To address this issue, physical-layer security has been recommended as a complementary solution in the literature. In this thesis, physical layer attacks of the cooperative communication systems are studied, and corresponding security techniques including cooperative jamming, beamforming and diversity approaches are investigated. In addition, a novel security solution for a two-hop decode-and-forward relaying system is presented where the transmitters insert a random phase shift to the modulated data of each hop. The random phase shift is created based on a shared secret among communicating entities. Thus, the injected phase shift confuses the eavesdropper and secrecy capacity improves. Furthermore, a cooperative jamming strategy for multi-hop decode-and-forward relaying systems is presented where multiple non-colluding illegitimate nodes can overhear the communication. The jamming signal is created by the transmitter of each hop while being sent with the primary signal. The jamming signal is known at the intended receiver as it is according to a secret common knowledge between the communicating entities. Hence, artificial noise misleads the eavesdroppers, and decreases their signal-to-noise-ratio. As a result, secrecy capacity of the system is improved. Finally, power allocation among friendly jamming and main signal is proposed to ensure that suggested scheme enhances secrecy

Experimental study to evaluate the pathogenicity of Streptococcus iniae in Guppy (Poecilia reticulata)

Streptococcus iniae has emerged as an important fish pathogen over the last decade in farmed rainbow trout in Iran. The main objective of this study was to evaluate the pathogenicity of S. iniae in Poecilia reticulata. Atotal of 60 apparently healthy P. reticulata were obtained from ornamental fish pet store and injected intraperitoneally with 1.5×106 cfu of bacteria. For 14 days after challenge, the rate of mortality and clinical signs were recorded. The first clinical signs was observed in challenged fish 48 hrs after injection of S. iniae and first mortality was observed 72 hrs after injection. No significant differences in mortality and clinical signs between both sexes were observed. Streptococcus iniae was collected from internal organs of fishes challenged, and was confirmed using the conventional biochemical tests and PCR. It is concluded that, P. reticulata is susceptible to streptococcosis and can play an important role in transmission of the disease to other ornamental fish species and also cultured fish

Original Article Prevalence and Antimicrobial Susceptibility of Bacteria Isolated from Surgical Site and Bloodstream Infections of Hospitalized Patients at a Tertiary Heart Center

ABSTRAC

Distribution of Class 1-3 Integrons in Carbapenem-Resistant Pseudomonas aeruginosa Isolated from Inpatients in Shiraz, South of Iran

BACKGROUND: Health-care-associated infection (HAI) is effect on patients for the time of staying in the hospital. Opportunistic pathogens including Pseudomonas aeruginosa are the most dangerous biological agents in nosocomial infections. This study aimed to assess the prevalence of 3 classes of integrons carrying to carbapenem resistance in P. aeruginosa strains collected from Nemazee hospital.METHODS: This cross-sectional study was conducted on clinical P. aeruginosa isolates were collected from Nemazee hospital. The identification of the isolates was performed by routine biochemical tests. Antimicrobial sensitivity testing was determined using the disk diffusion method against imipenem and meropenem. The int1, int2 and int3 genes were detected using the polymerase chain reaction (PCR).RESULTS: Seventy-five clinical isolates of P. aeruginosa were recovered from various clinical infections. A carbapenemresistant phenotype was detected in 42.7% (imipenem) and 29.3%(meropenem) of isolates. As the PCR results, 48 (64%) and 15 (20%) isolates were identified as being positive for class 1 and class 2 integrons, respectively. Class 3 integrons were not found among the studied isolates.CONCLUSIONS: Our data demonstrate the importance of class 1 and 2 integrons in carbapenem resistant P. aeruginosa strains. Therefore, integrons play an important role in acquisition and dissemination of carbapenem resistance genes among these pathogens, so, management of infection control policies and the appropriate use of antibiotics is essential for control the spreading of antibiotics resistance genes

A pilot study of the effects of crocin on high-density lipoprotein cholesterol uptake capacity in patients with metabolic syndrome: a randomized clinical trial

A randomized clinical trial high-density lipoprotein (HDL) cholesterol uptake capacity (CUC) is reduced in patients with metabolic syndrome (MetS). We have assessed the effect of crocin supplementation on HDL CUC in patients with MetS. Forty-four subjects with MetS were randomly allocated to one of two groups: one group received placebo and the other group received crocin at a dose of 30 mg (two tablets of 15 mg per day) for 8 weeks. Serum biochemical parameters were measured using an AutoAnalyzer BT3000 (BioTechnica). The modified CUC method is a cell free, simple, and high-throughput assay that used to evaluate HDL CUC of serum samples. The decision tree analysis was undertaken using JMP Pro (SAS) version 13. The mean age of the crocin and placebo groups were 38.97 ± 13.33 and 43.46 ± 12.77 years, respectively. There was a significant increase in serum HDL CUC in the crocin group compared to that of the placebo group in patients with MetS (p-value< 0.05). The decision tree analysis showed that serum HDL functionality was more important variable than HDL-C level in predicting patients with hypertension at baseline (p-value < 0.05). Crocin administration (30 mg for a period of 8 weeks) was found to improve serum HDL CUC in patients with MetS. Trial registration: IRCT2013080514279N1

Survival and clinical outcomes of patients with melanoma brain metastasis in the era of checkpoint inhibitors and targeted therapies

Abstract Background Melanoma brain metastasis is associated with an extremely poor prognosis, with a median overall survival of 4–5 months. Since 2011, the overall survival of patients with stage IV melanoma has been significantly improved with the advent of new targeted therapies and checkpoint inhibitors. We analyze the survival outcomes of patients diagnosed with brain metastasis after the introduction of these novel drugs. Methods We performed a retrospective analysis of our melanoma center database and identified 79 patients with brain metastasis between 2011 and 2015. Results The median time from primary melanoma diagnosis to brain metastasis was 3.2 years. The median overall survival duration from the time of initial brain metastasis was 12.8 months. Following a diagnosis of brain metastasis, 39 (49.4%), 28 (35.4%), and 24 (30.4%) patients were treated with anti-CTLA-4 antibody, anti-PD-1 antibody, or BRAF inhibitors (with or without a MEK inhibitor), with a median overall survival of 19.2 months, 37.9 months and 12.7 months, respectively. Factors associated with significantly reduced overall survival included male sex, cerebellar metastasis, higher number of brain lesions, and treatment with whole-brain radiation therapy. Factors associated with significantly longer overall survival included treatment with craniotomy, stereotactic radiosurgery, or with anti-PD-1 antibody after initial diagnosis of brain metastasis. Conclusions These results show a significant improvement in the overall survival of patients with melanoma brain metastasis in the era of novel therapies. In addition, they suggest the activity of anti-PD-1 therapy specifically in the setting of brain metastasis